Category: Synthases, Other
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The numbers above the group shows the mean fold-change for each mutant RBD
The numbers above the group shows the mean fold-change for each mutant RBD. hCoV-2IG demonstrate highly varied antibody epitope profile SARS-CoV-2 hCoV-2IG plenty neutralized SARS-CoV-2 variants better than CP Significant reduction of hCoV-2IG binding to RBD-E484K compared with unmutated RBD Higher hCoV-2IG dose would be required for SARS-CoV-2 variant infected individuals Biological sciences; Immunology; Immune…
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There is numerous evidence that glycosylation attached to the Fc fragment may, despite its very limited structural variability, be used by the immune system to fine-tune an immune response
There is numerous evidence that glycosylation attached to the Fc fragment may, despite its very limited structural variability, be used by the immune system to fine-tune an immune response. higher efficacy of therapeutic antibodies lacking the core fucose and also suggest a unique mechanism by which the immune system can regulate antibody-mediated effector functions. Keywords:immunoglobulin,…
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The diagnosis of acquired TTP was based on the following criteria: (1) thrombocytopenia (platelet count below 150?G/L) and MAHA (Coombs-negative anemia, elevated LDH, schistocytes within the blood smear); (2) deficient ADAMTS13 activity [<10%, measured from the FRETS-VWF73 assay (fluorescence resonance energy transfer-based method using a 73-amino-acid synthetic peptide), as explained below]; and (3) detectable anti-ADAMTS13 autoantibodies (by combining activity assays or ELISA, as explained below)
The diagnosis of acquired TTP was based on the following criteria: (1) thrombocytopenia (platelet count below 150?G/L) and MAHA (Coombs-negative anemia, elevated LDH, schistocytes within the blood smear); (2) deficient ADAMTS13 activity [