Category: Synthases, Other
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The diagnosis of acquired TTP was based on the following criteria: (1) thrombocytopenia (platelet count below 150?G/L) and MAHA (Coombs-negative anemia, elevated LDH, schistocytes within the blood smear); (2) deficient ADAMTS13 activity [<10%, measured from the FRETS-VWF73 assay (fluorescence resonance energy transfer-based method using a 73-amino-acid synthetic peptide), as explained below]; and (3) detectable anti-ADAMTS13 autoantibodies (by combining activity assays or ELISA, as explained below)
The diagnosis of acquired TTP was based on the following criteria: (1) thrombocytopenia (platelet count below 150?G/L) and MAHA (Coombs-negative anemia, elevated LDH, schistocytes within the blood smear); (2) deficient ADAMTS13 activity [